Horizon Genetic test
Horizon carrier screening

What is Horizon carrier screening?

The Horizon test will analyze the genes to identify whether you are a carrier, for up to 274 autosomal recessive and X-linked syndromes.
Knowing if you are a carrier for a particular genetic disease can help you better with your family planning or medical care, or both. Most people are carriers of at least one genetic disease, even if nobody in the family has that disease.

Is horizon right for you?
Is Horizon right for you?

We're here to help you find out

We're here to help you find out

We're here to help you find out


Why is this important?

Natera offers a simple test that helps identify carriers for more than 200 genetic diseases. This test offers several screening options, so your doctor can choose the entire panel or part of the panel, depending on your history or other factors.
Many of the diseases that the Horizon test can identify may be serious or may not occur in childhood, and others may be diagnosed only at an older age.

If you are planning to become pregnant or if you are already pregnant, you can choose to have a test for identifying carriers of genetic diseases. You will get a negative or positive response for each tested genetic disease. A negative result means that no mutation has been identified for the tested genetic disease which significantly reduces the possibility of being a carrier for that genetic disease.
Horizon provides information to families about the risk of developing a genetic disease and helps them make decisions about a future pregnancy.
What does it mean to be a carrier? A carrier of a genetic condition has a change (or “mutation”) in one gene copy of a pair of genes.
• Most people are carriers of at least four to six genetic conditions.
• Most carriers are healthy because the other copy of the gene works normally.
• Carrier couples are at increased chance to have a child with a genetic condition.
• Knowing carrier status of genetic conditions allows patients to make more informed reproductive decisions.

Why choose Horizon?

Horizon supports you by offering:
• One of the largest panels available – 274 unique conditions.
• Complimentary pre – and post-test genetic information sessions with board-certified genetic counselors.

• Next-generation sequencing – the latest technology – to provide better detection rates.
• One of the first labs to screen for Duchenne muscular dystrophy.
• Five screening panels customized for specific populations, and à la carte ordering options.

What do Horizon results tell me, and when?

Results are returned to the doctor in about 2-3 weeks.
A positive result means that a disease-causing or likely disease-causing mutation was detected. It is important to determine the partner’s carrier status, too, to understand the chances of passing a genetic condition to the child.

A negative result means that no mutations for the conditions screened were found. While a negative result indicates a significantly lower chance to be a carrier, carrier screening cannot detect all disease-causing mutations.
What are the reproductive options if a couple is carrier? If partners are both carriers of the same autosomal recessive condition, or if one partner is a carrier of an X-linked condition, the couple may consider:
• Natural conception, with an option of prenatal testing, such as amniocentesis or chorionic villi sampling, for the specific condition.
• In vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD)
• Use of a sperm or egg donorwho is not a carrier for the condition (if allowed in your country)
• Adoption

Conditions tested

We screen for 274 autosomal-recessive and X-linked genetic conditions, including:

Cystic Fibrosis

Horizon offers truly comprehensive screening of the cystic fibrosis gene via Next Generation Sequencing.

Fragile X

Horizon automatically detects AGG interruptions for select premutation carriers, further refining risk for an affected child.

Duchenne Muscular Dystrophy

The most common form of muscular dystrophy affecting children.


Including alpha thalassemia, beta thalassemia, and sickle-cell disease.

Spinal Muscular Atrophy (SMA)

Including enhanced SMA (2+0) screening which refines the chance to be a silent carrier.

Step 1

Requisition form

Step 2

Blood sample collected

Step 3

Sample shipped to the lab and analyzed

Step 4

Results sent to the doctor in about 2-3 weeks from receiving the sample in the lab.


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Is horizon right for you?
Is Horizon right for you?

We're here to help you find out

We're here to help you find out

We're here to help you find out